the effects of cyclin d1 and bcl-2 expressıon on aggressive behavior in basal cell and basosquamous carcinoma

نویسندگان

oya n. sivrikoz

gülşen kandiloğlu

چکیده

background and objective: clinical behavior of basal cell carcinoma (bcc) is known to be different according to histological growth pattern and basosquamous cell carcinomas (bsc) are known with their aggressive behavior and metastatic capacity. in this study, we evaluated bcl-2 and cyclin d1 expressions in bcc and bsc cases comparatively, to explore their predictive value on the aggressive behavior of these tumors.   methods: one hundred tumors belong to 92 patients diagnosed as basal cell carcinoma and basosquamous carcinoma were studied. basal cell carcinomas were classified as aggressive and non-aggressive types according to growth pattern. number of cyclin d1 and bcl-2 positive cells in immunohistochemically stained serial sections were scored as low (0-1 +) and high (2 and 3+) in all tumors. results: a statistically significant difference was found between non-aggressive (nodular type) and aggressive types (micronodular, infiltrative types and bsc) for these markers (p

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The Effects of Cyclin D1 and Bcl-2 Expressıon on Aggressive Behavior in Basal Cell and Basosquamous Carcinoma

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عنوان ژورنال:
iranian journal of pathology

ناشر: iranian society of pathology

ISSN 1735-5303

دوره 10

شماره 3 2015

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